Introducing a mammal-derived genome engineering enzyme for next-generation gene and cell therapy
Financing to fund SalioGen’s pipeline in genetic diseases, based on proprietary EDIT ‘gene coding’ platform to advance durable, safe and affordable non-viral gene therapies
Financing concurrent with strengthening of board of directors and scientific advisory board
BURLINGTON, Mass. – March 1, 2021 – SalioGen Therapeutics, a privately held biotechnology company advancing Exact DNA Integration Technology (EDIT) for non-viral gene therapy, today announced that it has closed a $20 million Series A financing. The round was led by PBM Capital, a healthcare-focused investment firm, and included other undisclosed investors. Proceeds from the financing will be used to support the preclinical validation of the Company’s proprietary Exact DNA Integration Technology (EDIT) platform for the development of durable, safe and affordable in vivo gene therapies, including initial data in SalioGen’s lead programs in familial hypercholesterolemia and inherited macular degeneration. In conjunction with the financing, SalioGen has strengthened its Board of Directors and its Scientific Advisory Board.
“We are thrilled to introduce SalioGen and the EDIT genome engineering platform, backed by the confidence of investors with an excellent track record and enthusiasm for potential breakthrough technologies,” said Ray Tabibiazar, M.D., chief executive officer and chairman of SalioGen. “We believe that SalioGen has identified an evolved approach to gene therapy that, grounded by the only mammal-derived genome engineering enzyme and unconstrained by the limits seen to date in the gene therapy space, should empower us to develop safe, lasting and affordable non-viral gene therapies with the potential to cure genetic diseases unaddressed by current gene therapy and gene editing approaches. We are grateful not only to have the support of such esteemed investors, but also to have assembled such a prestigious group of directors, scientific advisors and collaborators.”
Paul B. Manning, chairman and CEO of PBM Capital, added, “Having supported the earliest iterations of gene therapy, we recognize the field’s immense inherent value, the areas where it has grown and where needed improvements remain. We believe that SalioGen’s EDIT platform represents a quantum leap forward in gene therapy technology that can improve the quality of therapy for individual patients while scaling it to reach potentially millions of patients in need.”
SalioGen has assembled a prestigious leadership team with collective experience in human gene therapy, medical genetics, lipid nanoparticles and cell therapy. Concurrent with the financing, Sean Stalfort, president of PBM Capital, will join SalioGen’s Board of Directors. The Board will also include:
- Dr. Tabibiazar, CEO and chairman of SalioGen
- Joseph J. Higgins, M.D., president and chief scientific officer of SalioGen (previously at UniQure)
- Suku Nagendran, M.D., president of R&D at Jaguar Gene Therapy (formerly the chief medical officer of Avexis)
The Company’s founding Scientific Advisory Board will be chaired by molecular biologist and geneticist Nancy L. Craig, Ph.D., Professor Emerita, Johns Hopkins University School of Medicine. Other members of the founding Scientific Advisory Board include:
- Beverly Davidson, Ph.D., Chief Scientific Strategy Officer at CHOP Research Institute;
- Thomas Quertermous, M.D., past chair of Stanford Cardiovascular Research, Stanford University School of Medicine;
- Ronald M. Krauss, M.D., University of California, San Francisco, past advisor to National Cholesterol Education Program, leadership roles with the American Heart Association;
- Ellis J. Neufeld, M.D., Ph.D. Physician‐in‐Chief of St. Jude’s Children’s Hospital; and
- Jesse B. Owens, Ph.D., University of Hawaii
BTIG, LLC acted as exclusive placement agent for the offering.